The three layers of the heart from outer to inner are Epicardium, Myocardium, Endocardium.

• A. Epicardium, Endocardium, Myocardium
• B. Myocardium, Endocardium, Epicardium
• C. Epicardium, Myocardium, Endocardium
• D. Endocardium, Epicardium, Myocardium

Answer: (C)

Understanding the layers of the heart from outside to inside: the outermost layer is the epicardium, which is the visceral layer of the pericardium and forms the surface of the heart, housing the coronary vessels. Beneath that is the myocardium, the thick muscular layer made of cardiomyocytes responsible for the heart’s contractions. The innermost layer is the endocardium, a smooth endothelial lining that lines the heart chambers and covers the valves, continuing into the lining of the great vessels. This order—epicardium, myocardium, endocardium—matches both structure and function: a protective outer surface, a powerful pumping muscle, and a delicate inner lining that minimizes friction as blood flows. If the endocardium were placed on the outside, or the epicardium too deep, it would not reflect the true anatomy; the coronary vessels run within the epicardial layer to reach the myocardium, and the endocardium only lines the interior.