Diphenhydramine commonly causes which side effect?

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Multiple Choice

Diphenhydramine commonly causes which side effect?

Explanation:
Diphenhydramine is a first‑generation antihistamine that readily crosses into the brain. By blocking H1 receptors in the central nervous system, it dampens histaminergic signaling and produces sedation. This central sedative effect is the most characteristic and commonly observed side effect, so drowsiness is the best answer. While it can cause other effects like dry mouth or blurred vision from its anticholinergic actions, and less commonly nausea or headache, the hallmark feature is daytime sedation. Its sedating property is also why it’s sometimes used as a sleep aid, though caution is warranted, especially in the elderly or with alcohol use.

Diphenhydramine is a first‑generation antihistamine that readily crosses into the brain. By blocking H1 receptors in the central nervous system, it dampens histaminergic signaling and produces sedation. This central sedative effect is the most characteristic and commonly observed side effect, so drowsiness is the best answer. While it can cause other effects like dry mouth or blurred vision from its anticholinergic actions, and less commonly nausea or headache, the hallmark feature is daytime sedation. Its sedating property is also why it’s sometimes used as a sleep aid, though caution is warranted, especially in the elderly or with alcohol use.

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